> “These findings could help explain what happens when the body’s thermoreceptors become impaired in ageing and disease.”

> ...this new understanding of the body’s thermoreceptors could inform treatments for people struggling with thermal dysfunction.

It would be amazing if this research also led to a treatment for the rare symptom of temperature reversal caused by ciguatera fish poisoning (ciguatoxin neurotoxins) overstimulating one's nerves. I am not personally afflicted but have friends who have been; one is still dealing with various symptoms many years later.

Thats super interesting I've never heard of this before. It seems that toxin gives a persistent increase in the activity of the sodium channel(s) that make cold painful. I imagine similar to how cold water on frozen fingers feels burning hot.

Several years ago I went to a talk about a receptor (TRPM8) that is activated by cold and also minty flavors(!). Would be curious to know if your friends experience(d) mint as burning/uncomfortable. If not, it would suggest the pathology is linked to separate cold-sensing physiology/pathways/neurons than the common "cool" feeling most are familiar with.

get poisoned twice and flip the bit?

I'm only halfway through listening but this is a rad album! Thank you for sharing.

Welp, it's time for a Candyman remake that works this cemetery into the lore.

Pinch (or CMD + minus) zoom out slightly as a workaround.

Amazing resource - thank you for creating it!

We have "Red Gate in the Rain" by Kasamatsu Shiro [1] hanging in our home. I uploaded a photo of it and had a great time browsing other works by Shiro.

My wife also noted that we'll eventually inherit Shiro's "Snow Falling at Red Gate" [2], in the same series, from her aunt.

We've a couple other prints that I am going to search now... thanks again!

[1] https://ukiyo-e.org/image/artelino/30852g1

[2] https://ukiyo-e.org/image/jaodb/Kasamatsu_Shiro-No_Series-Sn...

Glad I was able to help, those are some great prints! fwiw, there is also an online catalog of Kasamatsu Shrio's prints and it looks like these are your prints there: https://shirokasamatsu.art/catalog/red-gate-in-the-rain/ https://shirokasamatsu.art/catalog/red-gate-in-the-snow/

I also understood it the way that you did, and got excited. Womp womp. I'm optimistic that it will be reality in the not too distant future though.

Wen Waymo Campervans?!

I never thought I’d see Ely mentioned on HN.

http://moosebay.com is a close family friend who lives in and guides out of Ely. I had a great trip there many years ago.

I’ll have to ask them about your story, surely they remember it happening.

Watched them in January this year, cold and windy and they were still going hard. It was a lot of fun!

For us Cloud SQL instances are toast but App Engine Standard instances are still serving requests. Google Cloud console is borked too, mostly just erroring out.