AS/400 still exists actually, under the name IBM i. I know a person who swears by them. It's a fascinating system. There are no files, only persistent objects living in a 128-bit address space. Downside: still uses EBCDIC….
Actually single-level store concept was introduced in Atlas, used in MULTICS, AS/400. [1]
Some modern and quite high-performance solutions are using this concept, e.g. LMDB [2]