The main problem I have is links. The printing to PDF doesn't care about <a> links. It will linkify anything that looks like a URL or an email address, but that means that I have to have JS put the url in, plus it's ugly to have the urls there at all.
As far as links go, I already treat the resume like a print document; all the URLs are written out explicitly, have their own lines where appropriate. (I guess that's why I haven't run into the problem yet.)