Right. I think that's why we get into the "let's try this" mode with doctors, which has been mentioned in this thread. That can be frustrating for patients, but "sertonergic drug" (or effect) is a hugely broad category, and we don't have any way to know in advance which part of what thing needs to be affected in what way -- or even if it's serotonin that's the problem!

I hear what you say about "reactive mind." I've never heard it put that way, but man does that capture depression/mania and a whole host of other brain cooties.